Medicine
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Construction and validation of a necroptosis-related prognostic signature in acute myeloid leukemia.
Acute myeloid leukemia (AML), an uncommonly low 5-year survival and high mortality rate, is a potentially catastrophic diagnosed subtype of leukemia. The development of new prognostic markers is urgently needed to guide its treatment. Necroptosis is a newly defined biological process for regulating cell death, and previous studies have confirmed that the abnormality of the physical function can lead to multiple malignancies. ⋯ L LNle. CHO, and AZD6244 negatively correlated with the NRG score. These drugs may provide a reference for subsequent treatment.
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Patients undergoing percutaneous coronary intervention mainly receive antiplatelet therapy. However, limited data are available regarding the optimal dual antiplatelet therapy (DAPT) following the implantation of new-generation drug-eluting stent (DES). ⋯ In patients undergoing implantation of a new-generation of DES, short-term (1-3 months) DAPT exhibited no inferiority compared with standard (12 months) DAPT in terms of all-cause mortality, cardiac death, myocardial infarction, stroke, and definite or probable stent thrombosis compared with standard (12 months) DAPT. However, short-term DAPT appeared superior to standard DAPT in terms of major bleeding and all bleeding.
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Review
Barriers and incentives influencing the use of partograph in Nigeria: A comprehensive review.
This comprehensive review examines the barriers and incentives influencing the use of partographs in maternal healthcare within Nigeria. Maternal mortality remains a critical concern in the country, making it imperative to evaluate the factors that shape the adoption of essential tools like the partograph. The literature review underscores the global significance of partograph utilization, emphasizing its role in improving maternal outcomes. ⋯ Through examining case studies, the review presents real-world examples that illustrate successful and challenging instances of partograph implementation. The article concludes with actionable recommendations to overcome identified barriers and enhance incentives for effectively integrating partographs into maternal healthcare practices in Nigeria. This study contributes valuable insights to the ongoing discourse on improving maternal healthcare, emphasizing the need for tailored strategies in the Nigerian context.
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Music therapy may have some potential in the pain control of extracorporeal shock wave lithotripsy, and this meta-analysis aims to study the analgesic efficacy of music therapy for extracorporeal shock wave lithotripsy. ⋯ Music therapy was effective to control the pain of extracorporeal shock wave lithotripsy.
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Review
Exploring the role of eosinophil cationic protein (ECP) in schizophrenia: Insights and implications.
Schizophrenia, a multifaceted neuropsychiatric disorder characterized by disruptions in perception, cognition, and behavior, has been associated with neuroinflammatory processes. Emerging research has increasingly recognized the potential involvement of immune-related factors in the pathogenesis of schizophrenia, prompting investigations into biomarkers associated with inflammatory cascades. Among these biomarkers, Eosinophil Cationic Protein (ECP), traditionally known for its role in eosinophil-mediated immune responses, has garnered attention for its putative association with neuroinflammation in schizophrenia. ⋯ Moreover, the potential implications of ECP in neuroinflammatory processes relevant to schizophrenia pathophysiology are discussed. ECP's role in modulating immune responses and its potential impact on neuronal function, synaptic plasticity, and neurotoxicity within the central nervous system (CNS) are considered, highlighting the potential contribution of ECP to the neuroinflammatory mechanisms underlying schizophrenia. In conclusion, while the precise role of ECP in schizophrenia pathogenesis warrants further elucidation, exploring its association with neuroinflammation holds promise in unraveling new biomarkers and therapeutic avenues for managing this complex psychiatric disorder.