Medicine
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The landscape of research roles within academic journals often remains uncharted territory, with authorial contributions frequently reduced to linear hierarchies (e.g., professor and assistant professor). The Kano model, traditionally used in customer satisfaction research, offers a nuanced framework for identifying the multifaceted roles of authors in scholarly publications. This study utilizes the Kano model to dissect and categorize the roles of authors in the medicine field. ⋯ The Kano model serves as an effective tool for uncovering the diverse contributions of authors in medical research. By moving beyond the lead and follower dichotomy, this study highlights the intricate ecosystem of authorial roles, emphasizing the importance of each in advancing knowledge within the field of medicine. Future application of the Kano model could foster a more collaborative and inclusive recognition of contributions across various disciplines.
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Most people diagnosed with chronic hepatitis B (CHB) need treatment to help reduce the risk of liver disease and limit disease transmission. Therapeutic vaccine (TV) candidates have been under study for their clinical effects on inducing HBV-specific host immune responses. This review aimed to systematically synthesize updated evidence on the efficacy and safety of TVs in patients with CHB. ⋯ In patients with CHB, TVs had significant effects on HBeAg SC compared to the SOC or placebo. There was no significant difference between serious adverse events. TVs are promising treatment strategy to overcome CHB.
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Meta Analysis
Efficacy and safety analysis of AKT inhibitor in triple-negative breast cancer: A meta-analysis and systematic review.
To determine the clinical benefit of monotherapy with AKT inhibitors in patients diagnosed with triple-negative breast cancer (TNBC). ⋯ AKT inhibitors showed slightly better efficacy in the treatment of TNBC. However, further studies are needed to evaluate its long-term safety and optimal regimen, and caution should be exercised in patients with coexisting gastrointestinal disorders. The clinical characteristics of the patients and the choice of drugs should be considered on an individual basis.
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Meta Analysis
A systematic review of the predictive value of radiomics for nasopharyngeal carcinoma prognosis.
Radiomics has been widely used in the study of tumours, which has predictive and prognostic value in nasopharyngeal carcinoma (NPC). Therefore, we collected relevant literature to explore the role of current radiomics in predicting the prognosis of NPC. ⋯ This study summarized all the studies that examined the predictive value of radiomics for NPC prognosis. Based on the summarized AUC values, as well as sensitivity and 1-specificity, it can be concluded that radiomics has good performance in predicting the prognosis of NPC. Radiomics models have certain advantages in predicting the effectiveness of PFS compared to predicting disease-free survival. It cannot be determined whether the combination model is superior to the radiomics model in predicting NPC prognosis, nor can it be determined whether imaging methods have differences in predictive ability. The findings confirmed and provided further evidence supporting the effectiveness of radiomics for the prediction of cancer prognosis.
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Review Case Reports
Peripheral ulcerative keratitis secondary to tuberculosis: A case report and literature review.
Compared with intraocular tuberculosis, ocular tuberculosis with ocular surface involvement is rare. Corneal involvement in ocular tuberculosis may include interstitial keratitis or peripheral ulcerative keratitis. We report a case of peripheral ulcerative keratitis directly caused by tuberculosis. ⋯ Peripheral ulcerative keratitis secondary to tuberculosis can be directly caused by M tuberculosis.