JAMA : the journal of the American Medical Association
-
Chronic kidney disease (CKD) is common. Kidney disease severity can be classified by estimated glomerular filtration rate (GFR) and albuminuria, but more accurate information regarding risk for progression to kidney failure is required for clinical decisions about testing, treatment, and referral. ⋯ A model using routinely obtained laboratory tests can accurately predict progression to kidney failure in patients with CKD stages 3 to 5.
-
A triple-marker approach for chronic kidney disease (CKD) evaluation has not been well studied. ⋯ Adding cystatin C to the combination of creatinine and ACR measures improved the predictive accuracy for all-cause mortality and end-stage renal disease.
-
Whole-genome sequencing is becoming increasingly available for research purposes, but it has not yet been routinely used for clinical diagnosis. ⋯ Whole-genome sequencing can identify cytogenetically invisible oncogenes in a clinically relevant time frame.