JAMA : the journal of the American Medical Association
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Latino populations have one of the highest prevalences of type 2 diabetes worldwide. ⋯ Using whole-exome sequencing, we identified a single low-frequency variant in the MODY3-causing gene HNF1A that is associated with type 2 diabetes in Latino populations and may affect protein function. This finding may have implications for screening and therapeutic modification in this population, but additional studies are required.