JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Multicenter Study Observational Study
Association between 7 years of intensive treatment of type 1 diabetes and long-term mortality.
Whether mortality in type 1 diabetes mellitus is affected following intensive glycemic therapy has not been established. ⋯ After a mean of 27 years' follow-up of patients with type 1 diabetes, 6.5 years of initial intensive diabetes therapy was associated with a modestly lower all-cause mortality rate when compared with conventional therapy.
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Type 1 diabetes has historically been associated with a significant reduction in life expectancy. Major advances in treatment of type 1 diabetes have occurred in the past 3 decades. Contemporary estimates of the effect of type 1 diabetes on life expectancy are needed. ⋯ Estimated life expectancy for patients with type 1 diabetes in Scotland based on data from 2008 through 2010 indicated an estimated loss of life expectancy at age 20 years of approximately 11 years for men and 13 years for women compared with the general population without type 1 diabetes.