JAMA : the journal of the American Medical Association
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Review
Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review.
The substantial growth over the last decade in the use of extracorporeal life support for adults with acute respiratory failure reveals an enthusiasm for the technology not always consistent with the evidence. However, recent high-quality data, primarily in patients with acute respiratory distress syndrome, have made extracorporeal life support more widely accepted in clinical practice. ⋯ The role of extracorporeal life support in the management of adults with acute respiratory failure is being redefined by advances in technology and increasing evidence of its effectiveness. Future developments in the field will result from technological advances, an increased understanding of the physiology and biology of extracorporeal support, and increased knowledge of how it might benefit the treatment of a variety of clinical conditions.
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Randomized Controlled Trial Multicenter Study
Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions.
The effect of intensive blood pressure lowering on brain health remains uncertain. ⋯ Among hypertensive adults, targeting an SBP of less than 120 mm Hg, compared with less than 140 mm Hg, was significantly associated with a smaller increase in cerebral white matter lesion volume and a greater decrease in total brain volume, although the differences were small.