JAMA : the journal of the American Medical Association
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Population-based assessment of disease risk associated with gene variants informs clinical decisions and risk stratification approaches. ⋯ In 2 large biobank cohorts, the estimated penetrance of pathogenic/loss-of-function variants was variable but generally low. Further research of population-based penetrance is needed to refine variant interpretation and clinical evaluation of individuals with these variant alleles.
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Editorial Comment
Booster Vaccination to Reduce SARS-CoV-2 Transmission and Infection.