JAMA : the journal of the American Medical Association
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JAMA
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Randomized Controlled Trial
Effect of Fibrinogen Concentrate on Intraoperative Blood Loss Among Patients With Intraoperative Bleeding During High-Risk Cardiac Surgery: A Randomized Clinical Trial.
Fibrinogen concentrate might partly restore coagulation defects and reduce intraoperative bleeding. ⋯ Among patients with intraoperative bleeding during high-risk cardiac surgery, administration of fibrinogen concentrate, compared with placebo, resulted in no significant difference in the amount of intraoperative blood loss.