JAMA : the journal of the American Medical Association
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Comparative Study
Medication errors and adverse drug events in pediatric inpatients.
Iatrogenic injuries, including medication errors, are an important problem in all hospitalized populations. However, few epidemiological data are available regarding medication errors in the pediatric inpatient setting. ⋯ Medication errors are common in pediatric inpatient settings, and further efforts are needed to reduce them.
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To comprehend the results of a randomized controlled trial (RCT), readers must understand its design, conduct, analysis, and interpretation. That goal can be achieved only through complete transparency from authors. Despite several decades of educational efforts, the reporting of RCTs needs improvement. ⋯ The diagram explicitly includes the number of participants, according to each intervention group, included in the primary data analysis. Inclusion of these numbers allows the reader to judge whether the authors have performed an intention-to-treat analysis. In sum, the CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Effectiveness of St John's wort in major depression: a randomized controlled trial.
Extracts of St John's wort are widely used to treat depression. Although more than 2 dozen clinical trials have been conducted with St John's wort, most have significant flaws in design and do not enable meaningful interpretation. ⋯ In this study, St John's wort was not effective for treatment of major depression.
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Studies have found that individuals who consume 1 alcoholic drink every 1 to 2 days have a lower risk of a first acute myocardial infarction (AMI) than abstainers or heavy drinkers, but the effect of prior drinking on mortality after AMI is uncertain. ⋯ Self-reported moderate alcohol consumption in the year prior to AMI is associated with reduced mortality following infarction.