JAMA : the journal of the American Medical Association
The most recent articles from:
JAMA
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Randomized Controlled Trial Multicenter Study Clinical Trial
Maintenance phase efficacy of sertraline for chronic depression: a randomized controlled trial.
The chronic form of major depression is associated with a high rate of prevalence and disability, but no controlled research has examined the impact of long-term treatment on the course and burden of illness. ⋯ Maintenance therapy with sertraline is well tolerated and has significant efficacy in preventing recurrence or reemergence of depression in chronically depressed patients.