JAMA : the journal of the American Medical Association
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JAMA
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To develop an objective method for assessing organ dysfunction among intensive care unit (ICU) patients on the first day of the ICU stay. ⋯ The LOD System provides an objective tool for assessing severity levels for organ dysfunction in the ICU, a critical component in the conduct of clinical trials. Neurologic, cardiovascular, and renal dysfunction were the most severe organ dysfunctions, followed by pulmonary and hematologic dysfunction, with hepatic dysfunction the least severe. The LOD System takes into account both the relative severity among organ systems and the degree of severity within an organ system.