The Journal of family practice
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LOMH is frequently observed in primary care, with an increasing prevalence in older men. The diagnosis is based on a combination of mostly nonspecific signs and symptoms and measurement of testosterone and other hormones. Various testosterone formulations are available to individualize therapy to restore the physiologic testosterone level and improve symptoms. Careful assessment must be undertaken prior to and during TRT to prevent harm, reduce adverse events, and foster adherence.
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DPN is a common complication of T2DM that often causes a pain syndrome. The diagnosis of DPNP centers around a careful history and physical examination, aided by the use of diagnostic tools, such as the 128-Hz tuning fork. A reduction in pain severity of 30% to 50% is achievable for most patients but generally requires combination therapy. ⋯ Of the adjuvant analgesics, the use of the tricyclic antidepressant and anticonvulsant groups is supported by the most extensive evidence. The selection of an adjuvant analgesic is often based on patient comorbidities and tolerability. Frequent follow-up is needed to optimize therapy.