Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jun 2014
Benefits, harms, and costs for breast cancer screening after US implementation of digital mammography.
Compared with film, digital mammography has superior sensitivity but lower specificity for women aged 40 to 49 years and women with dense breasts. Digital has replaced film in virtually all US facilities, but overall population health and cost from use of this technology are unclear. ⋯ The transition to digital breast cancer screening in the United States increased total costs for small added health benefits. The value of digital mammography screening among women aged 40 to 49 years depends on women's preferences regarding false positives.
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J. Natl. Cancer Inst. · Apr 2014
Randomized Controlled Trial Multicenter StudyMagnetic resonance-guided focused ultrasound for patients with painful bone metastases: phase III trial results.
Pain due to bone metastases is a common cause of cancer-related morbidity, with few options available for patients refractory to medical therapies and who do not respond to radiation therapy. This study assessed the safety and efficacy of magnetic resonance-guided focused ultrasound surgery (MRgFUS), a noninvasive method of thermal tissue ablation for palliation of pain due to bone metastases. ⋯ This multicenter phase III trial demonstrated that MRgFUS is a safe and effective, noninvasive treatment for alleviating pain resulting from bone metastases in patients that have failed standard treatments.