Journal of neurosurgery
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Journal of neurosurgery · Jul 2003
Clinical TrialEfficacy of moderate hypothermia in patients with severe head injury and intracranial hypertension refractory to mild hypothermia.
This study was performed to determine whether moderate hypothermia (31 degrees C) improves clinical outcome in severely head injured patients whose intracranial hypertension cannot be controlled using mild hypothermia (34 degrees C). ⋯ The authors concluded that moderate hypothermia is not effective in improving clinical outcomes in severely head injured patients whose ICP remains higher than 40 mm Hg after treatment with mild hypothermia combined with conventional therapies.
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Journal of neurosurgery · Jul 2003
Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage.
Matrix metalloproteinases (MMPs) are overexpressed in the presence of some neurological diseases in which blood-brain barrier disruption exists. The authors investigated the MMP-9 concentration in patients after acute intracerebral hemorrhage (ICH) and its relation to perihematomal edema (PHE). ⋯ Expression of MMP-9 is raised after acute spontaneous ICH. Among patients with deep ICH this increase is associated with PHE and the development of neurological worsening within the acute stage.