Journal of neurosurgery
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Journal of neurosurgery · Jan 2004
Proximal occlusion of the middle cerebral artery in C57Black6 mice: relationship of patency of the posterior communicating artery, infarct evolution, and animal survival.
The intraluminal suture model for focal cerebral ischemia is increasingly used, but not without problems. It causes hypothalamic injury, subarachnoid hemorrhage, and inadvertent premature reperfusion. The patency of the posterior communicating artery (PCoA) potentially affects the size of the infarct. In addition, survival at 1 week is unstable. The authors operated on C57Black6 mice to produce proximal middle cerebral artery occlusion (MCAO) so that drawbacks with the suture model could be circumvented. ⋯ This model provides not only a robust infarct size (which is not affected by the patency of the PCoA), but also a better survival rate.
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Journal of neurosurgery · Jan 2004
What we research: survey of American Association of Neurological Surgeons and Congress of Neurological Surgeons member publications.
The goal of this study was to create a searchable database of research manuscripts authored by members of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons (AANS/CNS) to describe the nature and character of the research currently being undertaken by neurosurgeons. ⋯ The majority of AANS/CNS member manuscripts are authored by non-US members despite their small AANS/CNS representation. Most research is clinical, based on retrospective data, and includes a large number of case reports. A disparity exists between what neurosurgeons do clinically and both the quantity and subject of their research.
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Interest has developed in the use of magnesium (Mg++) as a neuroprotectant and antivasospastic agent. Magnesium may increase cerebral blood flow (CBF) and reduce the contraction of cerebral arteries caused by various stimuli. In this study the authors tested the hypothesis that a continuous intravenous infusion of Mg++ reduces cerebral vasospasm after experimental subarachnoid hemorrhage (SAH). ⋯ Magnesium sulfate did not significantly reduce cerebral vasospasm after SAH in the doses tested. An investigation of SAH is warranted mainly to test whether a benefit can be achieved by neuroprotection or by augmentation of CBF by dilation of small vessels and/or collateral pathways.
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Journal of neurosurgery · Jan 2004
Case ReportsTransvertebral interbody cage and pedicle screw fixation for high-grade spondylolisthesis. Case report.
Surgical stabilization of high-grade lumbosacral spondylolisthesis is clinically challenging, and the success of deformity reduction and fusion varies. The authors describe a patient with Grade III spondylolisthesis at L5-S1. Partial reduction was achieved and fusion involved pedicle screw fixation and a posterior transvertebral interbody cage. ⋯ Clinical and early radiographic results were excellent. Transsacral cage fixation can be considered a viable option to buttress the region in which high-grade L5-S1 spondylolisthesis has been reduced. The cage provides substrate for interbody arthrodesis and acts as a biomechanical stabilizer that helps prevent pedicle screw failure.
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Journal of neurosurgery · Jan 2004
Comparative StudyPerformance of bipolar forceps during coagulation and its dependence on the tip material: a quantitative experimental assay. Technical note.
The aim of this study was to measure objectively the adherence of burned tissue to bipolar forceps to evaluate the coagulation performance of forceps made of different types of metals. Coagulation performance of bipolar forceps made of gold, titanium, and stainless steel was determined by comparing the amount of protein in the adhered coagulum on the tips. The amount of adhered coagulum was significantly less on the gold-plated bipolar forceps than on those made of the other two materials. ⋯ Histological examination of an artery coagulated with the gold-plated bipolar forceps showed that the structure had been completely collapsed without destruction of the layers, whereas arteries coagulated with the other materials revealed severely damaged structures. Adherence to bipolar forceps was dependent on both the material in the tips and the roughness of this material. The gold-plated bipolar forceps demonstrated the best performance.