Journal of neurosurgery
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Journal of neurosurgery · Jun 2014
Enhanced expression of proapoptotic and autophagic proteins involved in the cell death of glioblastoma induced by synthetic glycans.
Glioblastoma is the most aggressive malignant brain tumor, and overall patient survival has not been prolonged even by conventional therapies. Previously, the authors found that chemically synthesized glycans could be anticancer agents against growth of a series of cancer cells. In this study, the authors examined the effects of glycans on the growth of glioblastoma cells both in vitro and in vivo. ⋯ These results suggest that synthetic glycans could be a promising novel anticancer agent for performing chemotherapy against glioblastoma.