Journal of neurosurgery
-
Journal of neurosurgery · Jan 2016
Increased level of H19 long noncoding RNA promotes invasion, angiogenesis, and stemness of glioblastoma cells.
OBJECTIVE Increased levels of H19 long noncoding RNA (lncRNA) have been observed in many cancers, suggesting that overexpression of H19 may be important in the development of carcinogenesis. However, the role of H19 in human glioblastoma is still unclear. The object of this study was to examine the level of H19 in glioblastoma samples and investigate the role of H19 in glioblastoma carcinogenesis. ⋯ Finally, stable overexpression of H19 was associated with increased tumor growth in the murine xenograft model. CONCLUSIONS The results of this study suggest that increased expression of H19 lncRNA promotes invasion, angiogenesis, stemness, and tumorigenicity of glioblastoma cells. Taken together, these findings indicate that H19 plays an important role in tumorigenicity and stemness of glioblastoma and thus could be a therapeutic target for treatment of glioblastoma in the future.
-
Journal of neurosurgery · Jan 2016
Editorial CommentEditorial: Deep brain stimulation and intraoperative MRI.