Journal of neurosurgery
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The purpose of this study was to evaluate the results following Gamma Knife thalamotomy (GKT) for medically refractory essential tremor in a series of patients in whom open surgical techniques were not desirable. ⋯ Gamma Knife thalamotomy is a safe and effective therapy for medically refractory essential tremor. Its use is especially valuable for patients ineligible for radiofrequency thalamotomy or deep brain stimulation. Patients must be counseled on potential complications, including the low probability of a delayed neurological deficit.
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Journal of neurosurgery · Jan 2008
Combined internal uncusectomy and decompressive craniectomy for the treatment of severe closed head injury: experience with 80 cases.
Transtentorial brain herniation is a major cause of morbidity and death following severe closed head injury. The purpose of this study was to evaluate the efficacy of selective uncoparahippocampectomy and tentorial splitting as an adjuvant method of treating otherwise uncontrollable elevated intracranial pressure (ICP) while attempting to prevent or minimize the devastating consequences caused by transtentorial herniation. ⋯ A selective uncoparahippocampectomy with a tentorial edge incision and a wide decompressive craniectomy with duraplasty can be an effective adjuvant form of aggressive treatment to improve outcome in patients with severe closed head injury, especially in those who are younger if they are treated promptly.
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Journal of neurosurgery · Jan 2008
Honoring the 75th anniversary of the American Association of Neurological Surgeons.
Ever since the Journal of Neurosurgery (JNS) published its first volume in 1944, the journal has reflected the scientific, technical, and clinical evolution of our specialty and parent organization, first called the Harvey Cushing Society and later the American Association of Neurological Surgeons. The JNS has been an uncompromising arbiter of progress in our specialty, and its superb editorial stewardship has led to its recognition as the premier journal in the field. ⋯ We hope you will enjoy these articles and the accompanying commentaries. In this issue we present the next paper in this series.
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Relationships between industry and neurosurgeons engaged in both clinical practice and research have become increasingly complicated due to increased utilization of expensive devices in day-to-day neurosurgical practice. The Journal of Neurosurgery Publishing Group (JNSPG) has always had a policy of demanding open disclosure of any real, potential, or even perceived conflict of interest by authors submitting scientific manuscripts. ⋯ In addition, we felt that such a policy should be extended to all reviewers of articles submitted for publication to JNSPG journals-both members of the editorial boards and ad hoc reviewers. To clarify, extend, and specify the JNSPG's policy in this respect, the editor and editorial boards developed a task force on "Conflict of Interest." The task force, after considerable discussion with the full editorial boards, developed the following Conflict of Interest policy as well as the forms that submitting authors, editorial board members, and other reviewers are now required to complete.
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Journal of neurosurgery · Jan 2008
Normoxic ventilatory resuscitation following controlled cortical impact reduces peroxynitrite-mediated protein nitration in the hippocampus.
Ventilatory resuscitation with 100% O2 after severe traumatic brain injury (TBI) raises concerns about the increased production of reactive oxygen species (ROS). The product of peroxynitrite-meditated tyrosine residue nitration, 3-nitrotyrosine (3-NT), is a marker for oxidative damage to proteins. The authors hypothesized that posttraumatic resuscitation with hyperoxia (100% fraction of inspired oxygen [FiO2] concentration) results in increased ROS-induced damage to proteins compared with resuscitation using normoxia (21% FiO2 concentration). ⋯ In this clinically relevant model of TBI, normoxic resuscitation significantly reduced oxidative damage to proteins compared with hyperoxic resuscitation. Neuronal counts showed no benefit from hyperoxic resuscitation. These findings indicate that hyperoxic ventilation in the early stages after severe TBI may exacerbate oxidative damage to proteins.