Neuroscience letters
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Neuroscience letters · Aug 2013
Cortical activation during auditory elicitation of fear and disgust: a near-infrared spectroscopy (NIRS) study.
This near infrared spectroscopy study investigated whether nonverbal human sounds representing different basic emotions are able to specifically modulate temporo-parietal cortices, involved in auditory processing and attention. Forty-three adults (19 females and 24 males) were presented with sounds from the categories fear, disgust, and neutral. ⋯ The hemodynamic responses to disgusting sounds (e.g., sniffing, diarrhea) were smaller. Our findings point to a differential neuronal sensitivity of the human brain to two basic emotion elicitors in the auditory domain.
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Neuroscience letters · Aug 2013
Mu-opioidergic modulation differs in deep and superficial wide-dynamic range dorsal horn neurons in mice.
The spinal cord dorsal horn is an important action site for morphine analgesia. Wide-dynamic range (WDR) neurons in the dorsal horn are essential to spinal pain transmission and show increased excitability after repetitive noxious drive (windup). In light of differences in mu-opioid receptor distribution and neurophysiological properties of WDR neurons between deep and superficial dorsal horn, we recorded extracellular single-unit activity of WDR neurons from deep (350-700 μm) and superficial (<350 μm) dorsal horn in C57BL/6 mice and compared their responses to spinal superfusion of morphine (0.5mM, 30 μl) and naloxone (1mM, 30 μl). ⋯ In separate experiments, spinal administration of naloxone facilitated the development of windup to 0.2 Hz stimulation in deep (n=10), but not superficial (n=8), WDR neurons. Accordingly, morphine and naloxone modulation of neuronal activity may be related to a specific effect on neuronal sensitization/plasticity in deep WDR neurons, whereas morphine inhibition may depress acute noxious inputs to superficial WDR neurons. Our study suggests that mu-opioidergic modulation may be different in deep and superficial WDR neurons.
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Neuroscience letters · Aug 2013
Opposing effects of dexamethasone, agrin and sugammadex on functional innervation and constitutive secretion of IL-6 in in vitro innervated primary human muscle cells.
Neuromuscular junction development is the key process required for successful neuromuscular transmission and functional innervation of skeletal muscle fibres. Various substances can influence these processes, some of which are in common use in clinical practice. In the present study, the effects of the potentially new therapeutic agent agrin were followed, along with the widely used glucocorticoid dexamethasone. ⋯ Dexamethasone impaired functional innervation while agrin had opposing effects. Furthermore, based on interference with IL-6 secretion, we show potential (chemical) interactions between dexamethasone and sugammadex. The physiological effects of this interaction should be taken into consideration under clinical conditions where these two drugs might be applied simultaneously.