The New England journal of medicine
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Case Reports Retracted Publication
Images in clinical medicine. Complication of central venous catheterization.
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Randomized Controlled Trial Multicenter Study Comparative Study
Lapatinib plus capecitabine for HER2-positive advanced breast cancer.
Lapatinib, a tyrosine kinase inhibitor of human epidermal growth factor receptor type 2 (HER2, also referred to as HER2/neu) and epidermal growth factor receptor (EGFR), is active in combination with capecitabine in women with HER2-positive metastatic breast cancer that has progressed after trastuzumab-based therapy. In this trial, we compared lapatinib plus capecitabine with capecitabine alone in such patients. ⋯ Lapatinib plus capecitabine is superior to capecitabine alone in women with HER2-positive advanced breast cancer that has progressed after treatment with regimens that included an anthracycline, a taxane, and trastuzumab. (ClinicalTrials.gov number, NCT00078572 [ClinicalTrials.gov].).
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Letter Randomized Controlled Trial
Effects of dietary nitrate on blood pressure in healthy volunteers.
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Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal. ⋯ An evidence-based intervention resulted in a large and sustained reduction (up to 66%) in rates of catheter-related bloodstream infection that was maintained throughout the 18-month study period.