The New England journal of medicine
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Multicenter Study
Survival of patients with stage I lung cancer detected on CT screening.
The outcome among patients with clinical stage I cancer that is detected on annual screening using spiral computed tomography (CT) is unknown. ⋯ Annual spiral CT screening can detect lung cancer that is curable.
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Randomized Controlled Trial Multicenter Study
D-dimer testing to determine the duration of anticoagulation therapy.
The optimal duration of oral anticoagulation in patients with idiopathic venous thromboembolism is uncertain. Testing of D-dimer levels may play a role in the assessment of the need for prolonged anticoagulation. ⋯ Patients with an abnormal D-dimer level 1 month after the discontinuation of anticoagulation have a significant incidence of recurrent venous thromboembolism, which is reduced by the resumption of anticoagulation. The optimal course of anticoagulation in patients with a normal D-dimer level has not been clearly established. (ClinicalTrials.gov number, NCT00264277 [ClinicalTrials.gov].).
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Editorial Comment
Blueprint for a stronger Food and Drug Administration.