The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.
Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction. ⋯ Intracoronary administration of BMC is associated with improved recovery of left ventricular contractile function in patients with acute myocardial infarction. Large-scale studies are warranted to examine the potential effects of progenitor-cell administration on morbidity and mortality.
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Randomized Controlled Trial
Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction.
Previous studies have shown improvement in left ventricular function after intracoronary injection of autologous cells derived from bone marrow (BMC) in the acute phase of myocardial infarction. We designed a randomized, controlled trial to further investigate the effects of this treatment. ⋯ With the methods used, we found no effects of intracoronary injection of autologous mononuclear BMC on global left ventricular function.