The New England journal of medicine
The most recent articles from:
N. Engl. J. Med.
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Randomized Controlled Trial Multicenter Study
Homocysteine lowering and cardiovascular events after acute myocardial infarction.
Homocysteine is a risk factor for cardiovascular disease. We evaluated the efficacy of homocysteine-lowering treatment with B vitamins for secondary prevention in patients who had had an acute myocardial infarction. ⋯ Treatment with B vitamins did not lower the risk of recurrent cardiovascular disease after acute myocardial infarction. A harmful effect from combined B vitamin treatment was suggested. Such treatment should therefore not be recommended. (ClinicalTrials.gov number, NCT00266487.).
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Editorial Comment
Homocysteine trials--clear outcomes for complex reasons.