The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease.
Prophylactic transfusion prevents strokes in children with sickle cell anemia who have abnormalities on transcranial Doppler ultrasonographic examination. However, it is not known how long transfusion should be continued in these children. ⋯ Discontinuation of transfusion for the prevention of stroke in children with sickle cell disease results in a high rate of reversion to abnormal blood-flow velocities on Doppler studies and stroke. (ClinicalTrials.gov number, NCT00006182.)
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Editorial Comment
Aromatase inhibitors--a triumph of translational oncology.
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Randomized Controlled Trial Multicenter Study Comparative Study
A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer.
The aromatase inhibitor letrozole is a more effective treatment for metastatic breast cancer and more effective in the neoadjuvant setting than tamoxifen. We compared letrozole with tamoxifen as adjuvant treatment for steroid-hormone-receptor-positive breast cancer in postmenopausal women. ⋯ In postmenopausal women with endocrine-responsive breast cancer, adjuvant treatment with letrozole, as compared with tamoxifen, reduced the risk of recurrent disease, especially at distant sites. (ClinicalTrials.gov number, NCT00004205.)