The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Two-year outcomes after conventional or endovascular repair of abdominal aortic aneurysms.
Two randomized trials have shown better outcomes with elective endovascular repair of abdominal aortic aneurysms than with conventional open repair in the first month after the procedure. We investigated whether this advantage is sustained beyond the perioperative period. ⋯ The perioperative survival advantage with endovascular repair as compared with open repair is not sustained after the first postoperative year.
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Randomized Controlled Trial Clinical Trial
A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis.
Calcific aortic stenosis has many characteristics in common with atherosclerosis, including hypercholesterolemia. We hypothesized that intensive lipid-lowering therapy would halt the progression of calcific aortic stenosis or induce its regression. ⋯ Intensive lipid-lowering therapy does not halt the progression of calcific aortic stenosis or induce its regression. This study cannot exclude a small reduction in the rate of disease progression or a significant reduction in major clinical end points. Long-term, large-scale, randomized, controlled trials are needed to establish the role of statin therapy in patients with calcific aortic stenosis.
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Editorial Comment
Endovascular repair of abdominal aortic aneurysm--round two.