The New England journal of medicine
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Comment Letter
Endothelial protein C activation in meningococcal sepsis.
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Multicenter Study
Recurrent cerebrovascular events associated with patent foramen ovale, atrial septal aneurysm, or both.
Patent foramen ovale and atrial septal aneurysm have been identified as potential risk factors for stroke, but information about their effect on the risk of recurrent stroke is limited. We studied the risks of recurrent cerebrovascular events associated with these cardiac abnormalities. ⋯ Patients with both patent foramen ovale and atrial septal aneurysm who have had a stroke constitute a subgroup at substantial risk for recurrent stroke, and preventive strategies other than aspirin should be considered.
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Randomized Controlled Trial Clinical Trial
Fluconazole prophylaxis against fungal colonization and infection in preterm infants.
Invasive fungal infection is associated with substantial morbidity and mortality in preterm infants. We evaluated the efficacy of prophylactic fluconazole in preventing fungal colonization and invasive infection in extremely-low-birth-weight infants. ⋯ Prophylactic administration of fluconazole during the first six weeks of life is effective in preventing fungal colonization and invasive fungal infection in infants with birth weights of less than 1000 g.
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Review Case Reports
Clinical practice. Lowering cardiac risk in noncardiac surgery.