The New England journal of medicine
The most recent articles from:
N. Engl. J. Med.
-
Women with a BRCA1 or BRCA2 mutation have a high risk of breast cancer and may choose to undergo prophylactic bilateral total mastectomy. We investigated the efficacy of this procedure in such women. ⋯ In women with a BRCA1 or BRCA2 mutation, prophylactic bilateral total mastectomy reduces the incidence of breast cancer at three years of follow-up.
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite.
It is unclear whether antimicrobial treatment after an Ixodes scapularis tick bite will prevent Lyme disease. ⋯ A single 200-mg dose of doxycycline given within 72 hours after an I. scapularis tick bite can prevent the development of Lyme disease.