The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Clinical Trial
Atovaquone and azithromycin for the treatment of babesiosis.
Babesiosis is a tick-borne, malaria-like illness known to be enzootic in southern New England. A course of clindamycin and quinine is the standard treatment, but this regimen frequently causes adverse reactions and occasionally fails. A promising alternative treatment is atovaquone plus azithromycin. ⋯ For the treatment of babesiosis, a regimen of atovaquone and azithromycin is as effective as a regimen of clindamycin and quinine and is associated with fewer adverse reactions.
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Obesity and hypertension have been implicated as risk factors for the development of renal-cell cancer. ⋯ Higher body-mass index and elevated blood pressure independently increase the long-term risk of renal-cell cancer in men. A reduction in blood pressure lowers the risk.