The New England journal of medicine
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Editorial Comment
The enteroinsular axis revisited. A novel role for an incretin.
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Glucagon-like peptide-1 (7-36) amide (glucagon-like insulinotropic peptide, or GLIP) is a gastrointestinal peptide that potentiates the release of insulin in physiologic concentrations. Its effects in patients with diabetes mellitus are not known. ⋯ GLIP has an antidiabetogenic effect, and it may therefore be useful in the treatment of patients with NIDDM:
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Randomized Controlled Trial Clinical Trial
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment is often limited by side effects related to the drug's many pharmacologic actions. Selective agents might be safer and more effective. ⋯ Desipramine relieves pain caused by diabetic neuropathy with efficacy similar to that of amitriptyline, offering an alternative for patients unable to tolerate the latter. Blockade of norepinephrine reuptake is likely to mediate the analgesic effect of these antidepressant drugs in diabetic neuropathy. Fluoxetine, which blocks serotonin uptake, is no more effective than placebo for the relief of pain.