The New England journal of medicine
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Randomized Controlled Trial Clinical Trial
Intensive insulin therapy in critically ill patients.
Hyperglycemia and insulin resistance are common in critically ill patients, even if they have not previously had diabetes. Whether the normalization of blood glucose levels with insulin therapy improves the prognosis for such patients is not known. ⋯ Intensive insulin therapy to maintain blood glucose at or below 110 mg per deciliter reduces morbidity and mortality among critically ill patients in the surgical intensive care unit.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery.
Despite thromboprophylaxis, major knee surgery carries a high risk of venous thromboembolism. Fondaparinux, the first of a new class of synthetic antithrombotic agents, may reduce this risk. ⋯ In patients undergoing elective major knee surgery, postoperative treatment with 2.5 mg of fondaparinux once daily was significantly more effective in preventing deep-vein thrombosis than 30 mg of enoxaparin twice daily.