The New England journal of medicine
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Environmental lead exposure has been linked to alterations in growth and endocrine function. It is not known whether such exposure affects pubertal development. ⋯ These data suggest that environmental exposure to lead may delay growth and pubertal development in girls, although confirmation is warranted in prospective studies.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism.
Standard therapy to prevent recurrent venous thromboembolism includes 3 to 12 months of treatment with full-dose warfarin with a target international normalized ratio (INR) between 2.0 and 3.0. However, for long-term management, no therapeutic agent has shown an acceptable benefit-to-risk ratio. ⋯ Long-term, low-intensity warfarin therapy is a highly effective method of preventing recurrent venous thromboembolism.