The New England journal of medicine
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The role of tumor-infiltrating immune cells in the early metastatic invasion of colorectal cancer is unknown. ⋯ Signs of an immune response within colorectal cancers are associated with the absence of pathological evidence of early metastatic invasion and with prolonged survival.
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Editorial Comment
Professional behavior--a learner's permit for licensure.
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Randomized Controlled Trial Multicenter Study
Combined oral contraceptives in women with systemic lupus erythematosus.
Oral contraceptives are rarely prescribed for women with systemic lupus erythematosus, because of concern about potential negative side effects. In this double-blind, randomized, noninferiority trial, we prospectively evaluated the effect of oral contraceptives on lupus activity in premenopausal women with systemic lupus erythematosus. ⋯ Our study indicates that oral contraceptives do not increase the risk of flare among women with systemic lupus erythematosus whose disease is stable.
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Randomized Controlled Trial
Atrial overdrive pacing for the obstructive sleep apnea-hypopnea syndrome.
The role of atrial overdrive pacing (AOP) in sleep apnea remains uncertain. We prospectively evaluated the effect of AOP after 24 hours and after one month in patients with the obstructive sleep apnea-hypopnea syndrome and compared it with the use of nasal continuous positive airway pressure (n-CPAP). ⋯ Nasal continuous positive airway pressure therapy is highly effective for the treatment of the obstructive sleep apnea-hypopnea syndrome, whereas AOP has no significant effect.