The New England journal of medicine
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Randomized Controlled Trial Clinical Trial
A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis.
Calcific aortic stenosis has many characteristics in common with atherosclerosis, including hypercholesterolemia. We hypothesized that intensive lipid-lowering therapy would halt the progression of calcific aortic stenosis or induce its regression. ⋯ Intensive lipid-lowering therapy does not halt the progression of calcific aortic stenosis or induce its regression. This study cannot exclude a small reduction in the rate of disease progression or a significant reduction in major clinical end points. Long-term, large-scale, randomized, controlled trials are needed to establish the role of statin therapy in patients with calcific aortic stenosis.
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Editorial Comment
Endovascular repair of abdominal aortic aneurysm--round two.