The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
A randomized trial of deep-brain stimulation for Parkinson's disease.
Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management. ⋯ In this six-month study of patients under 75 years of age with severe motor complications of Parkinson's disease, neurostimulation of the subthalamic nucleus was more effective than medical management alone. (ClinicalTrials.gov number, NCT00196911 [ClinicalTrials.gov].).