The New England journal of medicine
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Randomized Controlled Trial
Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction.
Previous studies have shown improvement in left ventricular function after intracoronary injection of autologous cells derived from bone marrow (BMC) in the acute phase of myocardial infarction. We designed a randomized, controlled trial to further investigate the effects of this treatment. ⋯ With the methods used, we found no effects of intracoronary injection of autologous mononuclear BMC on global left ventricular function.
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Randomized Controlled Trial Multicenter Study
Oral fingolimod (FTY720) for relapsing multiple sclerosis.
Fingolimod (FTY720) is a new oral immunomodulating agent under evaluation for the treatment of relapsing multiple sclerosis. ⋯ In this proof-of-concept study, fingolimod reduced the number of lesions detected on MRI and clinical disease activity in patients with multiple sclerosis. Evaluation in larger, longer-term studies is warranted. (Clinicaltrials.gov numbers, NCT00333138 [core study] and NCT00235430 [ClinicalTrials.gov] [extension].).