The New England journal of medicine
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Randomized Controlled Trial
Capecitabine and oxaliplatin for advanced esophagogastric cancer.
We evaluated capecitabine (an oral fluoropyrimidine) and oxaliplatin (a platinum compound) as alternatives to infused fluorouracil and cisplatin, respectively, for untreated advanced esophagogastric cancer. ⋯ Capecitabine and oxaliplatin are as effective as fluorouracil and cisplatin, respectively, in patients with previously untreated esophagogastric cancer. (Current Controlled Trials number, ISRCTN51678883 [controlled-trials.com].).
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Editorial Comment
Survival after tachyarrhythmic arrest--what are we waiting for?
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Expert guidelines advocate defibrillation within 2 minutes after an in-hospital cardiac arrest caused by ventricular arrhythmia. However, empirical data on the prevalence of delayed defibrillation in the United States and its effect on survival are limited. ⋯ Delayed defibrillation is common and is associated with lower rates of survival after in-hospital cardiac arrest.