The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Adalimumab with or without methotrexate in juvenile rheumatoid arthritis.
Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid arthritis. We evaluated the efficacy and safety of adalimumab, a fully human monoclonal anti-TNF antibody, in children with polyarticular-course juvenile rheumatoid arthritis. ⋯ Adalimumab therapy seems to be an efficacious option for the treatment of children with juvenile rheumatoid arthritis. (ClinicalTrials.gov number, NCT00048542.)
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Editorial Comment
Human papillomavirus vaccination--reasons for caution.
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Randomized Controlled Trial Multicenter Study
Effect of PCI on quality of life in patients with stable coronary disease.
It has not been clearly established whether percutaneous coronary intervention (PCI) can provide an incremental benefit in quality of life over that provided by optimal medical therapy among patients with chronic coronary artery disease. ⋯ Among patients with stable angina, both those treated with PCI and those treated with optimal medical therapy alone had marked improvements in health status during follow-up. The PCI group had small, but significant, incremental benefits that disappeared by 36 months. (ClinicalTrials.gov number, NCT00007657.)