The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis.
Tofacitinib (CP-690,550) is a novel oral Janus kinase inhibitor that is being investigated as a targeted immunomodulator and disease-modifying therapy for rheumatoid arthritis. ⋯ In patients with active rheumatoid arthritis, tofacitinib monotherapy was associated with reductions in signs and symptoms of rheumatoid arthritis and improvement in physical function. (Funded by Pfizer; ORAL Solo ClinicalTrials.gov number, NCT00814307.).
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Multicenter Study Comparative Study Clinical Trial
Prospective trial of a pediatric ventricular assist device.
Options for mechanical circulatory support as a bridge to heart transplantation in children with severe heart failure are limited. ⋯ Our trial showed that survival rates were significantly higher with the ventricular assist device than with ECMO. Serious adverse events, including infection, stroke, and bleeding, occurred in a majority of study participants. (Funded by Berlin Heart and the Food and Drug Administration Office of Orphan Product Development; ClinicalTrials.gov number, NCT00583661.).