The New England journal of medicine
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Comment Letter
Daily chlorhexidine bathing and hospital-acquired infection.
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Randomized Controlled Trial Multicenter Study Comparative Study
Targeted versus universal decolonization to prevent ICU infection.
Both targeted decolonization and universal decolonization of patients in intensive care units (ICUs) are candidate strategies to prevent health care-associated infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). ⋯ In routine ICU practice, universal decolonization was more effective than targeted decolonization or screening and isolation in reducing rates of MRSA clinical isolates and bloodstream infection from any pathogen. (Funded by the Agency for Healthcare Research and the Centers for Disease Control and Prevention; REDUCE MRSA ClinicalTrials.gov number, NCT00980980).