The New England journal of medicine
-
Randomized Controlled Trial Multicenter Study Comparative Study
A trial comparing noninvasive ventilation strategies in preterm infants.
To reduce the risk of bronchopulmonary dysplasia in extremely-low-birth-weight infants, clinicians attempt to minimize the use of endotracheal intubation by the early introduction of less invasive forms of positive airway pressure. ⋯ Among extremely-low-birth-weight infants, the rate of survival to 36 weeks of postmenstrual age without bronchopulmonary dysplasia did not differ significantly after noninvasive respiratory support with nasal IPPV as compared with nasal CPAP. (Funded by the Canadian Institutes of Health Research; NIPPV ClinicalTrials.gov number, NCT00433212; Controlled-Trials.com number, ISRCTN15233270.).
-
Randomized Controlled Trial Multicenter Study
Faldaprevir and deleobuvir for HCV genotype 1 infection.
Interferon-free regimens would be a major advance in the treatment of patients with chronic hepatitis C virus (HCV) infection. ⋯ The rate of a sustained virologic response 12 weeks after the completion of therapy was 52 to 69% among patients who received interferon-free treatment with faldaprevir in combination with deleobuvir plus ribavirin. (Funded by Boehringer Ingelheim; SOUND-C2 ClinicalTrials.gov number, NCT01132313.).