The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Randomized Trial of Benznidazole for Chronic Chagas' Cardiomyopathy.
The role of trypanocidal therapy in patients with established Chagas' cardiomyopathy is unproven. ⋯ Trypanocidal therapy with benznidazole in patients with established Chagas' cardiomyopathy significantly reduced serum parasite detection but did not significantly reduce cardiac clinical deterioration through 5 years of follow-up. (Funded by the Population Health Research Institute and others; ClinicalTrials.gov number, NCT00123916; Current Controlled Trials number, ISRCTN13967269.).