The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis.
Early clinical studies suggested that the anti-interleukin-17 receptor A monoclonal antibody brodalumab has efficacy in the treatment of psoriasis. ⋯ Brodalumab treatment resulted in significant clinical improvements in patients with moderate-to-severe psoriasis. (Funded by Amgen; AMAGINE-2 and AMAGINE-3 ClinicalTrials.gov numbers, NCT01708603 and NCT01708629.).
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Randomized Controlled Trial Multicenter Study
Randomized Trial of Benznidazole for Chronic Chagas' Cardiomyopathy.
The role of trypanocidal therapy in patients with established Chagas' cardiomyopathy is unproven. ⋯ Trypanocidal therapy with benznidazole in patients with established Chagas' cardiomyopathy significantly reduced serum parasite detection but did not significantly reduce cardiac clinical deterioration through 5 years of follow-up. (Funded by the Population Health Research Institute and others; ClinicalTrials.gov number, NCT00123916; Current Controlled Trials number, ISRCTN13967269.).
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Historical Article
Transforming Turkey's Health System--Lessons for Universal Coverage.