The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy.
Ovarian failure is a common toxic effect of chemotherapy. Studies of the use of gonadotropin-releasing hormone (GnRH) agonists to protect ovarian function have shown mixed results and lack data on pregnancy outcomes. ⋯ Although missing data weaken interpretation of the findings, administration of goserelin with chemotherapy appeared to protect against ovarian failure, reducing the risk of early menopause and improving prospects for fertility. (Funded by the National Cancer Institute and others; POEMS/S0230 ClinicalTrials.gov number, NCT00068601.).
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Randomized Controlled Trial Multicenter Study
Long-term efficacy of a hepatitis E vaccine.
Hepatitis E virus (HEV) is a leading cause of acute hepatitis. The long-term efficacy of a hepatitis E vaccine needs to be determined. ⋯ Immunization with this hepatitis E vaccine induced antibodies against HEV and provided protection against hepatitis E for up to 4.5 years. (Funded by the Chinese Ministry of Science and Technology and others; ClinicalTrials.gov number, NCT01014845.).
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The agents most likely to be used in bioterrorism attacks are reviewed, along with the clinical syndromes they produce and their treatment.
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A study in drosophila shows that the progeny of male flies briefly fed a diet with abnormally high or low sugar levels are more susceptible to obesity. The data suggest that epigenetic susceptibility factors are at play not only in flies but in humans and mice as well.