The New England journal of medicine

The most recent articles from: N. Engl. J. Med. July 2015

N. Engl. J. Med. · Jul 2015

Case Reports

CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 23-2015. A 51-Year-Old Woman with Headache, Cognitive Impairment, and Weakness.

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N. Engl. J. Med. · Jul 2015

Review

Interventional Approaches to Gallbladder Disease.

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N. Engl. J. Med. · Jul 2015

Establishing a Global Vaccine-Development Fund.

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N. Engl. J. Med. · Jul 2015

Randomized Controlled Trial

AVI-7288 for Marburg Virus in Nonhuman Primates and Humans.

AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined. ⋯ This study shows that, on the basis of efficacy in nonhuman primates and pharmacokinetic data in humans, AVI-7288 has potential as postexposure prophylaxis for MARV infection in humans. (Funded by the Department of Defense; ClinicalTrials.gov number, NCT01566877.).

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N. Engl. J. Med. · Jul 2015

Editorial Comment

Nodal Irradiation after Breast-Cancer Surgery in the Era of Effective Adjuvant Therapy.

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