The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest.
Antiarrhythmic drugs are used commonly in out-of-hospital cardiac arrest for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia, but without proven survival benefit. ⋯ Overall, neither amiodarone nor lidocaine resulted in a significantly higher rate of survival or favorable neurologic outcome than the rate with placebo among patients with out-of-hospital cardiac arrest due to initial shock-refractory ventricular fibrillation or pulseless ventricular tachycardia. (Funded by the National Heart, Lung, and Blood Institute and others; ClinicalTrials.gov number, NCT01401647.).
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Editorial Comment
Preventing Food Allergy in Infancy - Early Consumption or Avoidance?
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Comment Letter
Wound Irrigation in Initial Management of Open Fractures.