The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery.
Atrial fibrillation after cardiac surgery is associated with increased rates of death, complications, and hospitalizations. In patients with postoperative atrial fibrillation who are in stable condition, the best initial treatment strategy--heart-rate control or rhythm control--remains controversial. ⋯ Strategies for rate control and rhythm control to treat postoperative atrial fibrillation were associated with equal numbers of days of hospitalization, similar complication rates, and similarly low rates of persistent atrial fibrillation 60 days after onset. Neither treatment strategy showed a net clinical advantage over the other. (Funded by the National Institutes of Health and the Canadian Institutes of Health Research; ClinicalTrials.gov number, NCT02132767.).
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Randomized Controlled Trial Comparative Study
Randomized Trial of a Lifestyle Program in Obese Infertile Women.
Small lifestyle-intervention studies suggest that modest weight loss increases the chance of conception and may improve perinatal outcomes, but large randomized, controlled trials are lacking. ⋯ In obese infertile women, a lifestyle intervention preceding infertility treatment, as compared with prompt infertility treatment, did not result in higher rates of a vaginal birth of a healthy singleton at term within 24 months after randomization. (Funded by the Netherlands Organization for Health Research and Development; Netherlands Trial Register number, NTR1530.).
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Letter Case Reports
A Mechanism for Cancer-Associated Membranous Nephropathy.
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Letter Case Reports
Visual Acuity after Retinal Gene Therapy for Choroideremia.