The New England journal of medicine
-
Randomized Controlled Trial Comparative Study
Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia.
The safety and efficacy of vaccines to prevent Ebola virus disease (EVD) were unknown when the incidence of EVD was peaking in Liberia. ⋯ A randomized, placebo-controlled phase 2 trial of two vaccines that was rapidly initiated and completed in Liberia showed the capability of conducting rigorous research during an outbreak. By 1 month after vaccination, the vaccines had elicited immune responses that were largely maintained through 12 months. (Funded by the National Institutes of Allergy and Infectious Diseases and the Liberian Ministry of Health; PREVAIL I ClinicalTrials.gov number, NCT02344407 .).
-
Comment Letter
Health Effects of Overweight and Obesity in 195 Countries.