The New England journal of medicine
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Comment Letter
Dengue Serostatus and Dengue Vaccine Safety and Efficacy.
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Randomized Controlled Trial Multicenter Study
Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea.
Antibiotic-resistant Neisseria gonorrhoeae has prompted the development of new therapies. Zoliflodacin is a new antibiotic that inhibits DNA biosynthesis. In this multicenter, phase 2 trial, zoliflodacin was evaluated for the treatment of uncomplicated gonorrhea. ⋯ The majority of uncomplicated urogenital and rectal gonococcal infections were successfully treated with oral zoliflodacin, but this agent was less efficacious in the treatment of pharyngeal infections. (Funded by the National Institutes of Health and Entasis Therapeutics; ClinicalTrials.gov number, NCT02257918 .).
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Daratumumab, a human IgG1κ monoclonal antibody targeting CD38, is used to treat multiple myeloma. We describe successful treatment with daratumumab in a case of treatment-refractory pure red-cell aplasia after ABO-mismatched allogeneic stem-cell transplantation. ⋯ Standard treatments had no effect. Within 1 week after the initiation of treatment with daratumumab, he no longer required transfusions.