The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents.
Dengue, a mosquito-borne viral disease, was designated a World Health Organization top 10 threat to global health in 2019. ⋯ TAK-003 was efficacious against symptomatic dengue in countries in which the disease is endemic. (Funded by Takeda Vaccines; TIDES ClinicalTrials.gov number, NCT02747927.).
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Fecal microbiota transplantation (FMT) is an emerging therapy for recurrent or refractory Clostridioides difficile infection and is being actively investigated for other conditions. We describe two patients in whom extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor by means of genomic sequencing. One of the patients died. Enhanced donor screening to limit the transmission of microorganisms that could lead to adverse infectious events and continued vigilance to define the benefits and risks of FMT across different patient populations are warranted.
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Editorial Comment
Fecal Microbiota Transplantation for Dysbiosis - Predictable Risks.