The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy.
E-cigarettes are commonly used in attempts to stop smoking, but evidence is limited regarding their effectiveness as compared with that of nicotine products approved as smoking-cessation treatments. ⋯ E-cigarettes were more effective for smoking cessation than nicotine-replacement therapy, when both products were accompanied by behavioral support. (Funded by the National Institute for Health Research and Cancer Research UK; Current Controlled Trials number, ISRCTN60477608 .).